What are the differences between aerobic and anaerobic glycolysis?

Question

Accepted Answer

Basis of differentiation

Aerobic glycolysis

Anaerobic glycolysis

Definition

Is a glycolysis pathway that occurs in the presence of oxygen

Is a glycolysis pathway that occurs in the absence of oxygen

Occurrence

Occurs only in eukaryotic cells

Occurs in both, prokaryotic and eukaryotic cells

Occurrence within the cell

Occurs in the cytoplasm and the mitochondria

Occurs only in the cytoplasm

Exchange of gases

Gases are exchanged

Gases are not exchanged

Phases

Proceeds through the Krebs cycle and oxidative phosphorylation

Proceeds either through lactic acid fermentation or ethanol fermentation

Fate of pyruvate

Pyruvate is oxidized into acetyl-CoA

Pyruvate is reduced to acetaldehyde in ethanol fermentation or lactate in lactic acid fermentation

End products

Carbon dioxide and water

Lactic acid or ethanol.

Efficiency & ATP production

Is a more efficient process, producing 32 ATPs per glucose molecule

Is a less efficient process, producing only 2 ATPs per glucose molecule

Cofactors

Generates 6 NADH, 2 GTPs,  and 2 FADH2, which undergo oxidative phosphorylation,

Generates only 4 NADH molecules, which regenerate through substrate-level phosphorylation

Basis of differentiation	Aerobic glycolysis	Anaerobic glycolysis
Definition	Is a glycolysis pathway that occurs in the presence of oxygen	Is a glycolysis pathway that occurs in the absence of oxygen
Occurrence	Occurs only in eukaryotic cells	Occurs in both, prokaryotic and eukaryotic cells
Occurrence within the cell	Occurs in the cytoplasm and the mitochondria	Occurs only in the cytoplasm
Exchange of gases	Gases are exchanged	Gases are not exchanged
Phases	Proceeds through the Krebs cycle and oxidative phosphorylation	Proceeds either through lactic acid fermentation or ethanol fermentation
Fate of pyruvate	Pyruvate is oxidized into acetyl-CoA	Pyruvate is reduced to acetaldehyde in ethanol fermentation or lactate in lactic acid fermentation
End products	Carbon dioxide and water	Lactic acid or ethanol.
Efficiency & ATP production	Is a more efficient process, producing 32 ATPs per glucose molecule	Is a less efficient process, producing only 2 ATPs per glucose molecule
Cofactors	Generates 6 NADH, 2 GTPs, and 2 FADH2, which undergo oxidative phosphorylation,	Generates only 4 NADH molecules, which regenerate through substrate-level phosphorylation