AAT Bioquest

What are the differences between chromatin and chromatids?

Posted July 28, 2023


Basis of differentiation




Chromatin is the readily stainable substance of a cell nucleus, consisting of DNA, RNA, and various proteins that form chromosomes during cell division

A chromatid is one of two genetically identical chromosome strands in which a chromosome splits longitudinally to prepare for cell division


Chromatin consists of DNA molecules wrapped around histone proteins, forming nucleosomes

Chromatids are replicated copies of a single chromosome that join together at the centrosome

Presence in cell cycle

Chromatin is present throughout the entire cell cycle, and uncoil to become less condensed following telophase

Chromatids are only present during the late stages of the cell cycle; they begin separating during metaphase and are at opposite poles of the cell during anaphase


Chromatin acts the template for gene expression and allows for the proper packaging and organization of DNA  (wrapped around histones)

Chromatids primarily function in the distribution of genetic material during cell division


When not dividing, chromatin exists as a filamentos and loose structure in the nucleus 

Chromatids consists of one DNA molecule that is tightly coiled and condensed 

Additional resources

Chromosomes and Chromatin

Chromatin Immunoprecipitation (ChIP)

Cell Cycle Assays


Helixyte™ Green ssDNA reagent

Hoechst 33258 *CAS 23491-45-4*