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AAT Bioquest

What are the differences between plasma membrane and cell membrane?

Posted October 19, 2022


Answer

Plasma membrane and cell membrane are two types of selectively semipermeable boundaries that are made up of a phospholipid bilayer. There are several differences between these two types of membranes. 

Basis of differentiationPlasma membraneCell membrane
DefinitionIs a semi-permeable barrier that encapsulates individual organelles in a cell or an entire cellIs a semipermeable membrane that surrounds the entire cell and its contents, including the cytoplasm and all the organelles
Structure and CompositionStructure and composition may vary depending on which organelle it surrounds and that organelle’s requirementsComposed of a phospholipid bilayer embedded with integral proteins that span the membrane, providing pathways for the movement of molecules through the membrane
Role in protecting again invadersDoes not play a protective rolePlays a role in protecting the cell from viral and bacterial invasions
Role in maintaining tonicity Does not play a role in maintaining tonicityPlays a role in maintaining correct tonicity
Functions 
  • Exact functions may vary depending on which organelle it is surrounding;
  • Providing a selectively permeable barrier between organelles and cytoplasm
  • Protecting the cell from outside invaders such as bacteria and viruses;
  • Regulating tonicity of cellular contents;
  • Providing a selectively permeable barrier;
  • Assists in signal transduction mechanisms at the cell surface
Feeding and movementAre not modified in any way; cilia may not be presentMay be modified in some organisms to facilitate movement and feeding; cilia may be present
Signal transdution Do not contain initial receptors for signal transduction mechanisms      Contains the initial receptors for signal transduction mechanisms
Role in cytokinesisDo not play a role in cytokinesisPlay a role in cytokinesis during cell division
Additional resources

Compartmentalization of the plasma membrane

Cell Navigator® Cell Plasma Membrane Staining Kit *Green Fluorescence*

iFluor® 488-Wheat Germ Agglutinin (WGA) Conjugate