Both chromatin and nucleosomes are structures made up of DNA wrapped around histone proteins. Additionally, both chromatin and nucleosomes play a role in the formation of chromosomes. Chromatin provides the structural framework for chromosomes, with nucleosomes serving as the building blocks of chromatin structure. Another similarity is that chromatin and nucleosomes are both terminologies used to describe the compacted state of DNA inside the nucleus of eukaryotic cells. Chromatin and nucleosomes are also both found in eukaryotes. Lastly, both chromatin and nucleosomes participate in the regulation of gene expression. The accessibility of DNA within nucleosomes and chromatin can be modulated through histone modifications and chromatin remodeling.