Despite the many differences between prokaryotic and eukaryotic DNA replication, there are also several similarities between them. These are some of the similarities between prokaryotic and eukaryotic DNA replication: 

• Both processes occur before nuclear division
• Both processes involve double-stranded DNA
• Both are multi-step processes carried by DNA polymerases
• RNA primers are necessary for initiation of both processes
• The RNA primer in both processes is synthesized by the enzyme primase
• DNA helicase is responsible for DNA unwinding in both processes
• Single-stranded DNA-binding proteins (SSB) stabilize the unwound DNA strands in both processes
• Both DNA replication processes occur in 5’ to 3’ direction
• Both are bi-directional as the replications progress in both ways
• Leading and lagging strands are formed in both types of replications
• In both DNA replications, small DNA fragments called Okazaki fragments are formed by the lagging strand