The differences between qubit and nanodrop are listed in the table below.
| Basis of differentiation | Qubit fluorometer | Nanodrop spectrophotometer |
| Sample volume requirement | 1-10 microliters | 0.5- 1 microliter |
| Principle | Fluorochrome chemistry | Spectroscopic analysis |
| Sample preparation | Required | Not required |
| Sample processing time | 2-5 minutes | < 1 minute |
| Quanlification range | 10 pg to 200 ng | 10 nanograms to 10 micrograms |