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Tide Quencher™ 8WS acid [TQ8WS acid]

Tide Quencher™ 8WS (TQ8WS) is a non-fluorescent molecule designed to efficiently quench the fluorescence of IR fluorophores such as ICG, iFluor® 820, iFluor® 840 and iFluor® 860. It has the longest absorption wavelength among all the commercial quenchers. TQ8WS is designed to be the most effective IR quencher with (a). much stronger absorption, and (b). much higher quenching efficiency for IR dyes. Tide Quencher™ 8WS acid is primarily used for labeling amino-modified oligonucleotides and peptides. It can be used in techniques such as polymerase chain reaction (PCR), real-time PCR, and DNA sequencing. In these applications, fluorescence signals are used to monitor the amplification or detection of specific DNA sequences. TQ8WS quenches the fluorescent signal until a specific event (like DNA strand separation or primer extension) occurs, leading to an increase in fluorescence that can be detected and quantified. Fluorescence resonance energy transfer (FRET)-based assays are widely used to detect and measure the presence of specific molecules in a sample. They involve the use of a fluorescent molecule (fluorophore) and a quencher molecule such as TQ8WS. The fluorophore emits light when excited by a specific wavelength of light, while the quencher molecule absorbs this emitted light, effectively "quenching" the fluorescence signal.

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References

View all 50 references: Citation Explorer
Specific Targeting and Labeling of Colonic Polyps in CPC-APC Mice with Mucin 5AC Fluorescent Antibodies: A Model for Detection of Early Colon Cancer.
Authors: Turner, Michael A and Cox, Kristin E and Liu, Shanglei and Neel, Nicholas and Amirfakhri, Siamak and Nishino, Hiroto and Hosseini, Mojgan and Alcantara, Joshua A and Abd El-Hafeez, Amer Ali and Lwin, Thinzar M and Mallya, Kavita and Pisegna, Joseph R and Singh, Satish K and Ghosh, Pradipta and Hoffman, Robert M and Batra, Surinder K and Bouvet, Michael
Journal: Current issues in molecular biology (2023): 3347-3358
Performance of two clinical fluorescence imaging systems with different targeted and non-targeted near-infrared fluorophores: a cadaveric explorative study.
Authors: Chiti, Lavinia E and Husi, Benjamin and Park, Brian and Beer, Patricia and D'Orchymont, Faustine and Holland, Jason P and Nolff, Mirja C
Journal: Frontiers in veterinary science (2023): 1091842
Optimizing Axial and Peripheral Substitutions in Si-Centered Naphthalocyanine Dyes for Enhancing Aqueous Solubility and Photoacoustic Signal Intensity.
Authors: Saad, Mohammad Ahsan and Pawle, Robert and Selfridge, Scott and Contreras, Leslie and Xavierselvan, Marvin and Nguyen, Christopher D and Mallidi, Srivalleesha and Hasan, Tayyaba
Journal: International journal of molecular sciences (2023)
Preclinical assessment of IRDye800CW-labeled gastrin-releasing peptide receptor-targeting peptide for near infrared-II imaging of brain malignancies.
Authors: Zhang, Yuan and Wang, Li and Zhang, Chengkai and Zhang, Jingjing and Yuan, Linhao and Jin, Shucheng and Zhou, Wenjianlong and Guan, Xiudong and Kang, Peng and Zhang, Chuanbao and Tian, Jie and Chen, Xiaoyuan and Li, Deling and Jia, Wang
Journal: Bioengineering & translational medicine (2023): e10532
Enhancing intraoperative tumor delineation with multispectral short-wave infrared fluorescence imaging and machine learning.
Authors: Waterhouse, Dale J and Privitera, Laura and Anderson, John and Stoyanov, Danail and Giuliani, Stefano
Journal: Journal of biomedical optics (2023): 094804
Page updated on December 6, 2024

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Catalog Number2130
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Physical properties

Molecular weight

877.90

Solvent

DMSO

Spectral properties

Absorbance (nm)

881

Storage, safety and handling

H-phraseH303, H313, H333
Hazard symbolXN
Intended useResearch Use Only (RUO)
R-phraseR20, R21, R22

Storage

Freeze (< -15 °C); Minimize light exposure
Tide Quencher™ 8WS (TQ8WS) is a non-fluorescent molecule designed to efficiently quench the fluorescence of IR fluorophores such as ICG, iFluor® 820, iFluor® 840 and iFluor® 860. It has the longest absorption wavelength among all the commercial quenchers.
Tide Quencher™ 8WS (TQ8WS) is a non-fluorescent molecule designed to efficiently quench the fluorescence of IR fluorophores such as ICG, iFluor® 820, iFluor® 840 and iFluor® 860. It has the longest absorption wavelength among all the commercial quenchers.
Tide Quencher™ 8WS (TQ8WS) is a non-fluorescent molecule designed to efficiently quench the fluorescence of IR fluorophores such as ICG, iFluor® 820, iFluor® 840 and iFluor® 860. It has the longest absorption wavelength among all the commercial quenchers.