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What are ASC oligomers?

Posted October 13, 2021


Answer

An ASC oligomer is an ASC (apoptosis-associated speck-like protein with a caspase-recruitment domain) that has transformed and re-nucleated into a new, typically larger structure in response to a pathogen or other inflammatory stimulus. It is an innate part of the biochemical system collectively known as the inflammasome. The newly formed ASC oligomer activates enzymes such as caspase-1, which then causes a myriad of other downstream effects.

Since it's such a useful marker for inflammasome activation, ASC oligomerization is measured by researchers studying inflammatory response, often using Western blot or other techniques.

Additional resources

Detection of Inflammasome Activation by P2X7 Purinoceptor Activation by Determining ASC Oligomerization

Cell Viability

Ac-DEVD-pNA *CAS 189950-66-1*