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What is "non canonical" inflammasome activation?

Posted October 11, 2021


Answer

There are two inflammasome activation pathways – canonical and non-canonical.

Canonical inflammasome activation is a caspase-1 dependent process.

Non-canonical inflammasome activation is dependent on caspase-4/5 in humans and caspase-11 in mice. The inflammatory caspases are capable of detecting intracellular LPS from gram-negative bacteria. Together with caspase-1, they cleave the pore forming protein gasdermin-D (GDMD). GSDMD makes the cell wall more permeable, and may trigger pyroptosis, a form of inflammatory programmed cell death. 

Additional resources

Non-canonical inflammasome activation targets caspase-11

Caspases

Caspase 1 (Ab-376) Antibody

5-FAM-YVAD-FMK