AAT Bioquest

What is the role of p53 in DNA damage repair system?

Posted July 22, 2020


Tumor protein p53 plays an important role in cell regulation and conserving the genomic stability, which is achieved by means of several mechanisms:

  • Activating DNA repair proteins when DNA has sustained damage.
  • Arresting growth by holding the cell cycle at the G1/S regulation point on DNA damage recognition.
  • Initiating apoptosis if DNA damage is irreparable.
  • Serving as a critical component for the senescence response to short telomeres.
Additional resources

Helixyte™ Green *10,000X Aqueous PCR Solution*

6-ROX glycine *25 uM fluorescence reference solution for PCR reactions*

Brooks, P. J. (1997). DNA damage, DNA repair, and alcohol toxicity—a review. Alcoholism: Clinical and Experimental Research, 21(6), 1073-1082.