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Why is phalloidin used in experiments that study actin?
Posted February 19, 2020
Actin
F-actin
actin
actin polymerization inhibitor
actin staining
fluorescently labeled phalloidin
phalloidin
Phalloidin
Answer
Phalloidin binds preferentially to actin filaments than to actin monomers, decreasing the rate constant for the dissociation of actin subunits from filament ends. This trait of phalloidin stabilizes actin filaments by preventing depolymerization.
Additional resources
Actin Structures and Filaments
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Why is phalloidin used in experiments that study actin?
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