What are the common conditions and disorders that affect T-cells?

T-cells may be affected by various autoimmune diseases and immunodeficiency disorders that compromise the immune system. Autoimmune diseases result due to a malfunctioning of the immune system that causes it to mistakenly attack the healthy cells in the body. Immunodeficiency disorders also weaken the immune system but they may be inherited or acquired. Some of the more common conditions and disorders that affect your T-cells include:

• Acquired Immune Deficiency Syndrome or AIDS – AIDs is caused by the Human immunodeficiency virus (HIV) that targets white blood cells, particularly CD4+ T-cells. 
• T-cell lymphomas – T-cell lymphomas refer to a group of blood cancers that originate in T-cells and spread affecting various tissues including the skin, subcutaneous tissue and lymph nodes. 
• Acute lymphocytic leukemia - Acute lymphocytic leukemia refers to a type of cancer that starts in the blood and bone marrow.
• Adult Hodgkin lymphoma - Adult Hodgkin lymphoma refers to a group of blood cancers that originate in the lymphatic system.
• Chronic T-cell leukemia – Also known as T-cell prolymphocytic leukemia, this is a type of blood cancer that originates in T-cells and can affect the lymph nodes, bone marrow, and blood.
• Job syndrome - A rare immune system disorder, Job syndrome predisposes individuals to recurrent infections.
• Severe combined immunodeficiency (SCID) – SCID refers to a group of rare inherited disorders caused by abnormalities related to T-cells and other lymphocytes that result in a compromised immune system.
• Thymic aplasia – Thymic aplasia is a condition wherein an individual may be born with an underdeveloped thymus, impacting T-cell maturation.
• DiGeorge syndrome – A genetic disorder, DiGeorge syndrome hinders the production of healthy T-cells resulting in an insufficiency.

Each of these conditions significantly affects the proper functioning of T-cells, leading to various health complications and challenges related to the immune response.