Noncoding RNAs are broken down into several classes.
MicroRNAs are approximately 18-22 nucleotides and function in the regulation of gene expression by binding to target mRNAs, leading to mRNA degradation or translational repression.
Long noncoding RNAsare typically longer than 200 nucleotides. They have diverse roles in gene regulation, including modulation of chromatin structure, transcriptional regulation, and translation.
Small interfering RNAsare approximately 20-25 nucleotides. They mediate the RNA interference (RNAi) pathway to degrade specific mRNAs or inhibit their translation.
Circular RNAsare 100-999 nucleotides long and are covalently closed loop structures. They regulate gene expression by acting as microRNA sponges, interacting with RNA-binding proteins.
Transfer RNAsare approximately 70-90 nucleotides. They function to carry amino acids to the ribosome during protein synthesis (translation).
Small nuclear RNAs (snRNAs) are typically 100-300 nucleotides in length and primarily function in the splicing of pre-mRNA molecules.