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AAT Bioquest

What are the roles of intermediate filaments in the cytoskeleton?

Posted March 27, 2023


Answer

Intermediate filaments are a primary component of the cytoskeleton. Intermediate filaments are very stable structures that are responsible for forming the true skeleton of the cell. When cells experience any type of mechanical stress, these filaments help to absorb that tension and prevent fractures. They help cells adhere to other cells, allowing the epithelial tissues to withstand tension. Additionally, they also help cells adhere to the extracellular matrix. Intermediate filaments also provide structure for internal organelles. For example, lamins form a cage around the nucleus to help keep it in place.    

Additional resources

Intermediate Filaments

Actin

Phalloidin-iFluor® 488 Conjugate