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What happens if there are too many adaptors attached to a DNA fragment?
Posted April 18, 2024
DNA and RNA QuantitationDNA FragmentationGene Expression Analysis & GenotypingNucleic AcidsNucleusSanger Sequencing
Answer
Excess adapters can lead to unwanted dimer formations, which may interfere with subsequent sequencing steps. If left unremoved, these contaminants and incorrectly sized fragments can reduce the efficiency and quality of sequencing. 
Additional resources
Adapter dimers causes, effects, and how to remove themDNA Fragmentation Gelite™ Green Nucleic Acid Gel Staining Kit

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