AAT Bioquest

What is the structure of a nuclear membrane?

Posted February 10, 2023


The nuclear membrane is made up of two phospholipid membranes that are organized in a bilayer arrangement, with an inner membrane and an outer membrane. The inner nuclear membrane or INM faces the nucleoplasm, while the outer nuclear membrane or ONM faces the cytoplasm. The inner and outer nuclear membranes are separated by a perinuclear space. A protein layer provides the nuclear membrane with additional strength and support. The outer membrane is continuous with the endoplasmic reticulum. Ribosomes cover the surface of the outer membrane and the rough endoplasmic reticulum. The inner nuclear membrane is connected to the nuclear lamina, which attaches and secures chromatin in the nucleoplasm. 

Additional resources

Nuclear envelope formation by chromatin-mediated reorganization of the endoplasmic reticulum


Nuclear Blue™ DCS1 *5 mM DMSO Solution*