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AAT Bioquest

Why is the stability of DNA templates so critical for non-dividing somatic cells?

Posted April 5, 2024


Answer

The stability of DNA templates is crucial for the framework and function of non-dividing somatic cells. In these cells, the unchanging DNA sequence is essential. As there are no frequent DNA checks and repair mechanisms, maintaining stable DNA is therefore vital to prevent genetic mutations. Stable DNA guarantees that each instance of protein synthesis yields uniform RNA transcripts, supporting consistency in cellular mechanisms. 

Additionally, DNA instability in non-dividing somatic cells can lead to the accumulation of mutations over time, which may contribute to the development of age-related diseases such as cancer. Therefore, maintaining stable DNA templates is also essential for reducing the risk of disease onset.

Additional resources

DNA Damage & Repair: Mechanisms for Maintaining DNA Integrity

DNA and RNA Quantitation

Helixyte™ Green Fluorimetric Total Nucleic Acid Quantitation Kit *Optimized for Microplate Readers*

DNA Concentration Calculator