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Tide Quencher™ 3WS maleimide [TQ3 maleimide]
Ordering information
| Price | |
| Catalog Number | |
| Unit Size | |
| Quantity |
Additional ordering information
| Telephone | 1-800-990-8053 |
| Fax | 1-800-609-2943 |
| sales@aatbio.com | |
| International | See distributors |
| Bulk request | Inquire |
| Custom size | Inquire |
| Shipping | Standard overnight for United States, inquire for international |
Physical properties
| Molecular weight | 1034.13 |
| Solvent | DMSO |
Spectral properties
| Absorbance (nm) | 579 |
| Correction Factor (260 nm) | 0.186 |
| Correction Factor (280 nm) | 0.205 |
| Extinction coefficient (cm -1 M -1) | 90000 |
Storage, safety and handling
| H-phrase | H303, H313, H333 |
| Hazard symbol | XN |
| Intended use | Research Use Only (RUO) |
| R-phrase | R20, R21, R22 |
| Storage | Freeze (< -15 °C); Minimize light exposure |
| UNSPSC | 12352200 |
Related products
| Overview |  SDSProtocol |
Molecular weight 1034.13 | Absorbance (nm) 579 | Correction Factor (260 nm) 0.186 | Correction Factor (280 nm) 0.205 | Extinction coefficient (cm -1 M -1) 90000 |
Tide Quencher™ 3WS (TQ3WS) has been developed as an advanced quenching agent, exhibiting superior properties over traditional quenchers such as TAMRA, TF3, and Cy3. The TQ3WS quencher offers: (a) significantly increased absorption coefficients; (b) enhanced quenching efficiencies; (c) high aqueous solubility; and (d) diverse reactive derivatives suitable for conjugation with oligonucleotides and peptides. Notably, TQ3WS is the most water-soluble non-fluorescent quencher currently available for oligonucleotide and peptide applications. Our research demonstrates that TQ3WS significantly enhances the solubility of hydrophobic peptides in aqueous environments. Furthermore, TQ3WS maleimide exhibits specific and efficient reactivity with thiol groups under mildly acidic to neutral pH conditions, making it a versatile tool in bioconjugation chemistry.
Calculators
Common stock solution preparation
Table 1. Volume of DMSO needed to reconstitute specific mass of Tide Quencher™ 3WS maleimide [TQ3 maleimide] to given concentration. Note that volume is only for preparing stock solution. Refer to sample experimental protocol for appropriate experimental/physiological buffers.
| 0.1 mg | 0.5 mg | 1 mg | 5 mg | 10 mg | |
| 1 mM | 96.7 µL | 483.498 µL | 966.996 µL | 4.835 mL | 9.67 mL |
| 5 mM | 19.34 µL | 96.7 µL | 193.399 µL | 966.996 µL | 1.934 mL |
| 10 mM | 9.67 µL | 48.35 µL | 96.7 µL | 483.498 µL | 966.996 µL |
Molarity calculator
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| Mass (Calculate) | Molecular weight | Volume (Calculate) | Concentration (Calculate) | Moles | ||||
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Spectrum
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Spectral properties
| Absorbance (nm) | 579 |
| Correction Factor (260 nm) | 0.186 |
| Correction Factor (280 nm) | 0.205 |
| Extinction coefficient (cm -1 M -1) | 90000 |
Product Family
| Name | Extinction coefficient (cm -1 M -1) | Correction Factor (260 nm) | Correction Factor (280 nm) |
| Tide Quencher™ 2WS maleimide [TQ2WS maleimide] | 48000 | 0.100 | 0.120 |
| Tide Quencher™ 4WS maleimide [TQ4WS maleimide] | 900001 | 0.149 | 0.136 |
| Tide Quencher™ 5WS maleimide [TQ5WS maleimide] | 130000 | 0.072 | 0.082 |
| Tide Quencher™ 6WS maleimide [TQ6WS maleimide] | 130000 | 0.120 | 0.102 |
| Tide Quencher™ 7WS maleimide [TQ7WS maleimide] | 140000 | 0.072 | 0.091 |
| Tide Quencher™ 1 maleimide [TQ1 maleimide] | 20000 | 0.147 | 0.194 |
| Tide Quencher™ 3 maleimide [TQ3 maleimide] | 22000 | 0.085 | 0.091 |
| Tide Quencher™ 3WS acid [TQ3WS acid] | 90000 | 0.186 | 0.205 |
| Tide Fluor™ 3WS maleimide [TF3WS maleimide] *Superior replacement for Cy3* | 150000 | - | 0.079 |