Purified Anti-human CD200 Antibody *OX-104*

OX-104 is an anti-human monoclonal antibody that forms an immune complex with the CD200 antigen. CD200 (sometimes referred to as OX-2 or OX2) is a single-pass type i membrane protein that is expressed on the surface of cells like stem cells, dendritic cells, B cells and endothelial cells. CD200 has been thought to be involved with vital biological processes such as cell-cell adhesion, especially heterotypic cell-cell adhesion. In addition, in many organisms, it suppresses neuron death, is a negative regulator of macrophage activation and is a negative regulator of interleukin-6 secretion. From a research standpoint, it is of biological interest due to its association with important macromolecules/ligands such as CD200R1. CD200 is a fairly uncommon antibody target, with a little more than 2000 publications in the last decade. Even still, CD200 is commonly used in flow cytometry applications as a phenotypic marker for differentiation of cell types, specifically in the study of neuroscience and immunology. This antibody was purified through affinity chromatography.