Abbreviation of Common Chemical Compounds Related to Peptides

Below is a list of common abbreviations found in peptide and oligonucleotide synthesis. Use CTRL + F to search this list

Abbreviation	Stands For	Also Known As	Examples
β-Ala	beta-alanine	β-Alanine
1-Nal	β-(1-Naphthyl)-L-alanine	3-(1-Naphthyl)-L-alanine
2-Nal	β-(2-Naphthyl)-L-alanine
4-MbNA	4-Methoxy-β-naphthylamide
AFC	7-Amino-4-trifluoromethyl-coumarin		AFC [7-Amino-4-trifluoromethylcoumarin] *CAS 53518-15-3* Ac-DEVD-AFC *CAS 201608-14-2* Z-DEVD-AFC
AMC	7-Amino-4-methyl-coumaride		AMC [7-Amino-4-methylcoumarin] *CAS 26093-31-2* BOC-Val-Pro-Arg-AMC Suc-LLVY-AMC
Abu	L-α-Aminobutyric acid
Abz	2-Aminobenzoyl	Anthraniloyl
Ac	Acetyl (Ac) group. N-terminal acetylation		Ac-IETD-AMC Ac-IETD-AFC *CAS 211990-57-7* Z-IETD-AFC *CAS 219138-02-0*
Acm	Acetamidomethyl
Ada	Adamantyl
Aha	7-Aminoheptanoic acid
Ahx	6-Aminohexanoic acid (Ahx, C6)	C6	DNP-X acid [6-(2,4-Dinitrophenyl)aminohexanoic acid] *CAS 10466-72-5* DNP-X acid, SE [6-(2,4-Dinitrophenyl)aminohexanoic acid, succinimidyl ester] *CAS 82321-04-8*
Aib	α-Aminoisobutyric acid	α-Methyl-alanine
Aloc	Allyloxycarbonyl
Aph	Aminophenylalanine
Arg(Me2)	N,N-dimethyl-L-arginine
Asu	L-α-Aminosuberic acid	L-2-Aminooctanoic acid
Benzoyl	Benzoyl	Bz C6H5CO-	Benzoyl-Arg-AMC Benzoyl-Leu-Gly-Arg-Aminoluciferin
Boc	tert-butoxycarbonyl	tert-butyloxycarbonyl	BOC-Val-Pro-Arg-AMC N-BOC-ethylenediamine *CAS 57260-73-8* BOC-Val-Pro-Arg-Aminoluciferin
Bom	Benzyloxymethyl
Bpa	4-Benzoyl-L-phenylalanine
Bzl	Benzyl		BC-NH2 [O6-(4-Aminomethyl-benzyl)guanine] Resorufin benzyl ether *CAS 87687-02-3* BG-NH2 [O6-(4-Aminomethyl-benzyl)guanine]
CHO	aldehyde functional group	formyl functional group	Ac-DEVD-CHO *CAS 169332-60-9* Ac-IETD-CHO *CAS 191338-86-0* Ac-VAD-CHO [Caspase Inhibitor II]
CMK	Chloromethylketone
Cbz	Benzyloxycarbonyl	Z	Z-Gly-Pro-AMC *CAS 68542-93-8* (Z-DEVD)2-R110 Z-DEVD-AFC
Cha	Cyclohexylalanine
Chg	L-Cyclohexylglycine
Cit	L-Citrulline
DCHA	Dicyclohexylammonium salt
DL-Asp	DL-Aspartic acid
DNP	2,4-Dinitrophenyl		DNP-X acid [6-(2,4-Dinitrophenyl)aminohexanoic acid] *CAS 10466-72-5* DNP-X acid, SE [6-(2,4-Dinitrophenyl)aminohexanoic acid, succinimidyl ester] *CAS 82321-04-8* DNP amine
DOTA	1,4,7,10-tetraazacyclododecane-N,N,N,N-tetraacetic acid
Dab	L-α,γ-Diaminobutyric acid
Dabcyl	4-(4-Dimethylaminophenylazo)benzoyl		DABCYL acid [4-((4-(Dimethylamino)phenyl)azo)benzoic acid] *CAS 6268-49-1* DABCYL succinimidyl ester [4-((4-(Dimethylamino)phenyl)azo)benzoic acid, succinimidyl ester] *CAS 146998-31-4* DABSYL chloride [4-Dimethylaminoazobenzene-4-sulfonyl chloride] *CAS 56512-49-3*
Dansyl	5-(Dimethylamino) naphthalene-1-sulfonyl		Dansyl chloride [5-Dimethylaminonaphthalene-1-sulfonyl chloride] *CAS 605-65-2* Dansyl cadaverine [5-Dimethylaminonaphthalene-1-(N-(5-aminopentyl))sulfonamide] Dansyl-X, SE
Dap	Diaminopimelic acid		FMOC-Dap(Boc)-OH *CAS 162558-25-0*
Dde	1-(4,4-Dimethyl-2,6-dioxocyclohex-1-ylidene)ethyl
Decy	decanoyl	CH3(CH2)8CO-
Dpr	2,3-Diaminopropionic acid	2,3-diaminopropionate
EDANS	5-[(2-Aminoethyl)amino]naphthalene-1-sulfonyl		EDANS sodium salt [5-((2-Aminoethyl)aminonaphthalene-1-sulfonic acid, sodium salt] *CAS 100900-07-0* EDANS acid [5-((2-Aminoethyl)amino)naphthalene-1-sulfonic acid] *CAS 50402-56-7* EDANS iodoacetamide [5-((((2-Iodoacetyl)amino)ethyl)amino)naphthalene-1-sulfonic acid]
FAM	Carboxyfluorescein		5-FAM [5-Carboxyfluorescein] *CAS 76823-03-5* 5(6)-FAM [5-(and-6)-Carboxyfluorescein] *CAS 72088-94-9* 5-FAM, SE [5-Carboxyfluorescein, succinimidyl ester] *CAS 92557-80-7*
FITC	Fluorescein isothiocyanate		5-FITC [Fluorescein-5-isothiocyanate] *CAS 3326-32-7* FITC-xtra FITC-C6-DEVD-FMK
FMK	Fluoromethylketone		FAM-VAD-FMK FITC-C6-DEVD-FMK FITC-C6-D(OMe)E(OMe)VD(OMe)-FMK
Fm	Fluorenylmethyl
Fmoc	9-Fluorenylmethyloxycarbonyl		FMOC-Lys(5-TAMRA)-OH FMOC-Lys(5-FITC)-OH FMOC-Lys(5-FAM)-OH *CAS 1242933-88-5*
Furoyl	Furan-2-carbonyl
GABA	Gamma-aminobutyric acid
Gla	γ-Carboxy-L-glutamic acid
Glp	Pyroglutamic Acid	pGlu Pyr
Homoarg	L-Homoarginine	L-α-Amino-ε-guanidinohexanoic acid
Homocit	L-Homocitrulline	L-α-Amino-ε-ureidohexanoic acid
Hse	Homoserine
Hyp	trans-4-Hydroxy-L-proline
Lys(Me)	N-methyl lysine
Lys(Me1)	N-methyl lysine
Lys(Me2)	N-dimethyl lysine
Lys(Me3)	N-trimethyl lysine
MBHA	4-Methylbenzhydrylamine
Mbs	4-Methoxybenzenesulfonyl
Mbzl	4-Methylbenzyl		BC-NH2 [O6-(4-Aminomethyl-benzyl)guanine] BG-NH2 [O6-(4-Aminomethyl-benzyl)guanine]
Mca	(7-Methoxycoumarin-4-yl)acetyl		MCA [7-Methoxycoumarin-4-acetic acid] *CAS 62935-72-2* MCA succinimidyl ester [7-Methoxycoumarin-4-acetic acid, succinimidyl ester]
Me	methyl functional group	R-CH3	TMRM [Tetramethylrhodamine methyl ester] *CAS#: 115532-50-8* MCLA [2-Methyl-6-(4-methoxyphenyl)-3,7-dihydroimidazo[1,2-a]pyrazin-3-one, hydrochloride] *CAS 128322-44-1* D-Luciferin methyl ester *CAS 73918-26-0*
MeAla	N-methyl alanine
MeNle	N-methyl-L-norleucine
MeOSuc	Methoxysuccinyl		MeO-Succ-Arg-Pro-Tyr-AMC
Met(O)	L-Methionine sulfoxide
Met(O)2	L-Methionine sulfone
Mmt	4-Methoxytrityl
Mob	4-Methoxybenzyl
Mpr	3-Mercaptopropionyl
Mtt	4-Methyltrityl
Myr	myristyl functional group	Myristic acid CH3(CH2)12-
N3	azide functional group	+N=-N–N–R	5-FAM Azide 5-TAMRA azide Biotin Azide
NHEt	Ethylamide
NHMe	N-Methylamide
NHNH2	Hydrazide		iFluor® 488 hydrazide Biotin hydrazide *CAS 66640-86-6* Cyanine 7 hydrazide [equivalent to Cy7® hydrazide]
NHOH	Hydroxamate
NMP	N-Methylpyrrolidine
NMe2	N,N-Dimethylamide
NO2	Nitro		pNPP [4-Nitrophenyl phosphate, disodium salt] *CAS 4264-83-9* 2-NBDG [2-(N-(7-Nitrobenz-2-oxa-1,3-diazol-4-yl)Amino)-2-Deoxyglucose] *CAS#: 186689-07-6* NBD-Cl [4-Chloro-7-nitrobenzofurazan] *CAS 10199-89-0*
NOTA	1,4,7-triazacyclononane-N,N,N-triacetic acid
NPys	3-Nitro-2-pyridinesulfenyl
Nal	β-(1-Naphthyl)-L-alanine (3-(1-Naphthyl)-L-alanine)
Nic	Nicotinyl
Nle	Norleucine
Nps	2-Nitrophenylsulfenyl
OBzl	Benzyl ester
OEt	Ethyl ester		TMRE [Tetramethylrhodamine ethyl ester] *CAS#: 115532-52-0* Zinquin ethyl ester *UltraPure grade* D-Luciferin ethyl ester *CAS 135251-85-3*
OFm	Fluorenylmethyl ester
OHex	Hexyl ester		Rhodamine B, hexyl ester, perchlorate
OMe	Methyl ester		TMRM [Tetramethylrhodamine methyl ester] *CAS#: 115532-50-8* D-Luciferin methyl ester *CAS 73918-26-0*
ONp	p-Nitrophenyl ester
OPcp	Pentachlorophenyl ester
OPfp	Pentafluorophenyl ester
OPh	Phenyl ester
OSu	Succinimide ester		ICG-OSu ICG-Sulfo-OSu ICG Xtra-OSu
OcHex	Cyclohexyl ester
Oic	L-Octahydroindole-2-carboxylic acid
Orn	Ornithine
OtBu	t-Butyl ester
PEG	Polyethylene glycol		FMOC-Glu(biotinyl-PEG)-OH Glucose-UDP-(PEG)6-Fluorescein Conjugate MM(PEG)24 Methyl-PEG-Maleimide Reagent
PEG2	Polyethylene glycol	--CH2-CH2-O-CH2-CH2-O-CH2-CH2--	Biotin PEG2 amine *CAS 138529-46-1* Biotin PEG2 maleimide *CAS 305372-39-8* Biotin PEG2 succinimidyl ester
PEG4	Polyethylene glycol	--CH2-CH2-O-CH2-CH2-O-CH2-CH2-O-CH2-CH2-O-CH2-CH2--	Biotin PEG4 succinimidyl ester Phalloidin-PEG4-DBCO DBCO-PEG4-NHS Ester
Pal	2-Pyridylalanine		(Ac-PAL)2R110
Palmitoyl	Palmitic acid group
Pbf	2,2,4,6,7-Pentamethyldihydrobenzofuran-5-sulfonyl
Pen	L-Penicillamine	β,β-Dimethyl-L-cysteine
Phaa	Phenylacetic acid
Phg	L-Phenylglycine
Pmp	β-Mercapto-β,β-cyclopentamethylene propionic acid
R110	Rhodamine 110		Rhodamine 110 *CAS 13558-31-1* Bis-L-Aspartic acid Beta-rhodamine 110 Bis-Arg-rhodamine 110
Sar	Sarcosine	N-Methylglycine
Sta	Statyl-((3S,4S)-4-amino-3-hydroxy-6-methylheptanoyl)		BOC-Statine [BOC-Sta(3S,4S)-OH] *CAS 58521-49-6* FMOC-Statine [FMOC-Sta(3S,4S)-OH] *CAS 158257-40-0*
Suc	Succinyl		Suc-LLVY-AMC (Suc-LLVY)2R110 Suc-LLVY-Aminoluciferin
TAMRA	Carboxytetramethyl rhodamine		5(6)-TAMRA [5(6)-Carboxytetramethylrhodamine] *CAS 98181-63-6* 6-TAMRA, SE [6-Carboxytetramethylrhodamine, succinimidyl ester] *CAS#: 150810-69-8* 5(6)-TAMRA, SE [5-(and-6)-Carboxytetramethylrhodamine, succinimidyl ester] *CAS 246256-50-8*
Tfa	Trifluoroacetyl
Thi	β-2-Thienylalanine
Tic	L-1,2,3,4-Tetrahydroisoquinoline-3-carboxylic acid
Tle	tert-butyl-leucine
Tos	Tosyl	4-Toluenesulfonyl
Trt	Trityl	triphenylmethyl Tr
Tyr(Me)	Methyltyrosine
Xan	Xanthyl
gamma-Glu	γ-L-Glutamyl-
iPr	iso-propyl
p-nitro-Phe	para-nitro-phenylalanine
pNA	p-Nitroanilide		Ac-DEVD-pNA *CAS 189950-66-1* Z-IETD-pNA *CAS 219138-21-3* Z-DEVD-pNA
pSer	Phospho-L-serine
pThr	Phospho-L-threonine
pTyr	Phospho-L-tyrosine
tBu	t-Butyl
β-NA	β-Naphthylamide

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Original created on April 24, 2020, last updated on April 24, 2020
Tagged under: Oligonucleotide Labeling, Peptide Labeling