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Abbreviation of Common Chemical Compounds Related to Peptides

Below is a list of common abbreviations found in peptide and oligonucleotide synthesis. Use CTRL + F to search this list

Abbreviation Stands For Also Known As Examples
β-Ala beta-alanine β-Alanine  
1-Nal β-(1-Naphthyl)-L-alanine 3-(1-Naphthyl)-L-alanine  
2-Nal β-(2-Naphthyl)-L-alanine    
4-MbNA 4-Methoxy-β-naphthylamide    
AFC 7-Amino-4-trifluoromethyl-coumarin   AFC [7-Amino-4-trifluoromethylcoumarin] *CAS 53518-15-3*
Ac-DEVD-AFC *CAS 201608-14-2*
Z-DEVD-AFC
AMC 7-Amino-4-methyl-coumaride   AMC [7-Amino-4-methylcoumarin] *CAS 26093-31-2*
BOC-Val-Pro-Arg-AMC
Suc-LLVY-AMC
Abu L-α-Aminobutyric acid    
Abz 2-Aminobenzoyl Anthraniloyl  
Ac Acetyl (Ac) group. N-terminal acetylation   Ac-IETD-AMC
Ac-IETD-AFC *CAS 211990-57-7*
Z-IETD-AFC *CAS 219138-02-0*
Acm Acetamidomethyl    
Ada Adamantyl    
Aha 7-Aminoheptanoic acid    
Ahx 6-Aminohexanoic acid (Ahx, C6) C6 DNP-X acid [6-(2,4-Dinitrophenyl)aminohexanoic acid] *CAS 10466-72-5*
DNP-X acid, SE [6-(2,4-Dinitrophenyl)aminohexanoic acid, succinimidyl ester] *CAS 82321-04-8*
Aib α-Aminoisobutyric acid α-Methyl-alanine  
Aloc Allyloxycarbonyl    
Aph Aminophenylalanine    
Arg(Me2) N,N-dimethyl-L-arginine    
Asu L-α-Aminosuberic acid L-2-Aminooctanoic acid  
Benzoyl Benzoyl Bz
C6H5CO-
Benzoyl-Arg-AMC
Benzoyl-Leu-Gly-Arg-Aminoluciferin
Boc tert-butoxycarbonyl tert-butyloxycarbonyl BOC-Val-Pro-Arg-AMC
N-BOC-ethylenediamine *CAS 57260-73-8*
BOC-Val-Pro-Arg-Aminoluciferin
Bom Benzyloxymethyl    
Bpa 4-Benzoyl-L-phenylalanine    
Bzl Benzyl   BC-NH2 [O6-(4-Aminomethyl-benzyl)guanine]
Resorufin benzyl ether *CAS 87687-02-3*
BG-NH2 [O6-(4-Aminomethyl-benzyl)guanine]
CHO aldehyde functional group formyl functional group Ac-DEVD-CHO *CAS 169332-60-9*
Ac-IETD-CHO *CAS 191338-86-0*
Ac-VAD-CHO [Caspase Inhibitor II]
CMK Chloromethylketone    
Cbz Benzyloxycarbonyl Z Z-Gly-Pro-AMC *CAS 68542-93-8*
(Z-DEVD)2-R110
Z-DEVD-AFC
Cha Cyclohexylalanine    
Chg L-Cyclohexylglycine    
Cit L-Citrulline    
DCHA Dicyclohexylammonium salt    
DL-Asp DL-Aspartic acid    
DNP 2,4-Dinitrophenyl   DNP-X acid [6-(2,4-Dinitrophenyl)aminohexanoic acid] *CAS 10466-72-5*
DNP-X acid, SE [6-(2,4-Dinitrophenyl)aminohexanoic acid, succinimidyl ester] *CAS 82321-04-8*
DNP amine
DOTA 1,4,7,10-tetraazacyclododecane-N,N,N,N-tetraacetic acid    
Dab L-α,γ-Diaminobutyric acid    
Dabcyl 4-(4-Dimethylaminophenylazo)benzoyl   DABCYL acid [4-((4-(Dimethylamino)phenyl)azo)benzoic acid] *CAS 6268-49-1*
DABCYL succinimidyl ester [4-((4-(Dimethylamino)phenyl)azo)benzoic acid, succinimidyl ester] *CAS 146998-31-4*
DABSYL chloride [4-Dimethylaminoazobenzene-4-sulfonyl chloride] *CAS 56512-49-3*
Dansyl 5-(Dimethylamino) naphthalene-1-sulfonyl   Dansyl chloride [5-Dimethylaminonaphthalene-1-sulfonyl chloride] *CAS 605-65-2*
Dansyl cadaverine [5-Dimethylaminonaphthalene-1-(N-(5-aminopentyl))sulfonamide]
Dansyl-X, SE
Dap Diaminopimelic acid   FMOC-Dap(Boc)-OH *CAS 162558-25-0*
Dde 1-(4,4-Dimethyl-2,6-dioxocyclohex-1-ylidene)ethyl    
Decy decanoyl CH3(CH2)8CO-  
Dpr 2,3-Diaminopropionic acid 2,3-diaminopropionate  
EDANS 5-[(2-Aminoethyl)amino]naphthalene-1-sulfonyl   EDANS sodium salt [5-((2-Aminoethyl)aminonaphthalene-1-sulfonic acid, sodium salt] *CAS 100900-07-0*
EDANS acid [5-((2-Aminoethyl)amino)naphthalene-1-sulfonic acid] *CAS 50402-56-7*
EDANS iodoacetamide [5-((((2-Iodoacetyl)amino)ethyl)amino)naphthalene-1-sulfonic acid]
FAM Carboxyfluorescein   5-FAM [5-Carboxyfluorescein] *CAS 76823-03-5*
5(6)-FAM [5-(and-6)-Carboxyfluorescein] *CAS 72088-94-9*
5-FAM, SE [5-Carboxyfluorescein, succinimidyl ester] *CAS 92557-80-7*
FITC Fluorescein isothiocyanate   5-FITC [Fluorescein-5-isothiocyanate] *CAS 3326-32-7*
FITC-xtra
FITC-C6-DEVD-FMK
FMK Fluoromethylketone   FAM-VAD-FMK
FITC-C6-DEVD-FMK
FITC-C6-D(OMe)E(OMe)VD(OMe)-FMK
Fm Fluorenylmethyl    
Fmoc 9-Fluorenylmethyloxycarbonyl   FMOC-Lys(5-TAMRA)-OH
FMOC-Lys(5-FITC)-OH
FMOC-Lys(5-FAM)-OH *CAS 1242933-88-5*
Furoyl Furan-2-carbonyl    
GABA Gamma-aminobutyric acid    
Gla γ-Carboxy-L-glutamic acid    
Glp Pyroglutamic Acid pGlu
Pyr
 
Homoarg L-Homoarginine L-α-Amino-ε-guanidinohexanoic acid  
Homocit L-Homocitrulline L-α-Amino-ε-ureidohexanoic acid  
Hse Homoserine    
Hyp trans-4-Hydroxy-L-proline    
Lys(Me) N-methyl lysine    
Lys(Me1) N-methyl lysine    
Lys(Me2) N-dimethyl lysine    
Lys(Me3) N-trimethyl lysine    
MBHA 4-Methylbenzhydrylamine    
Mbs 4-Methoxybenzenesulfonyl    
Mbzl 4-Methylbenzyl   BC-NH2 [O6-(4-Aminomethyl-benzyl)guanine]
BG-NH2 [O6-(4-Aminomethyl-benzyl)guanine]
Mca (7-Methoxycoumarin-4-yl)acetyl   MCA [7-Methoxycoumarin-4-acetic acid] *CAS 62935-72-2*
MCA succinimidyl ester [7-Methoxycoumarin-4-acetic acid, succinimidyl ester]
Me methyl functional group R-CH3 TMRM [Tetramethylrhodamine methyl ester] *CAS#: 115532-50-8*
MCLA [2-Methyl-6-(4-methoxyphenyl)-3,7-dihydroimidazo[1,2-a]pyrazin-3-one, hydrochloride] *CAS 128322-44-1*
D-Luciferin methyl ester *CAS 73918-26-0*
MeAla N-methyl alanine    
MeNle N-methyl-L-norleucine    
MeOSuc Methoxysuccinyl   MeO-Succ-Arg-Pro-Tyr-AMC
Met(O) L-Methionine sulfoxide    
Met(O)2 L-Methionine sulfone    
Mmt 4-Methoxytrityl    
Mob 4-Methoxybenzyl    
Mpr 3-Mercaptopropionyl    
Mtt 4-Methyltrityl    
Myr myristyl functional group Myristic acid
CH3(CH2)12-
 
N3 azide functional group +N=-N–N–R 5-FAM Azide
5-TAMRA azide
Biotin Azide
NHEt Ethylamide    
NHMe N-Methylamide    
NHNH2 Hydrazide   iFluor® 488 hydrazide
Biotin hydrazide *CAS 66640-86-6*
Cyanine 7 hydrazide [equivalent to Cy7® hydrazide]
NHOH Hydroxamate    
NMP N-Methylpyrrolidine    
NMe2 N,N-Dimethylamide    
NO2 Nitro   pNPP [4-Nitrophenyl phosphate, disodium salt] *CAS 4264-83-9*
2-NBDG [2-(N-(7-Nitrobenz-2-oxa-1,3-diazol-4-yl)Amino)-2-Deoxyglucose] *CAS#: 186689-07-6*
NBD-Cl [4-Chloro-7-nitrobenzofurazan] *CAS 10199-89-0*
NOTA 1,4,7-triazacyclononane-N,N,N-triacetic acid    
NPys 3-Nitro-2-pyridinesulfenyl    
Nal β-(1-Naphthyl)-L-alanine (3-(1-Naphthyl)-L-alanine)    
Nic Nicotinyl    
Nle Norleucine    
Nps 2-Nitrophenylsulfenyl    
OBzl Benzyl ester    
OEt Ethyl ester   TMRE [Tetramethylrhodamine ethyl ester] *CAS#: 115532-52-0*
Zinquin ethyl ester *UltraPure grade*
D-Luciferin ethyl ester *CAS 135251-85-3*
OFm Fluorenylmethyl ester    
OHex Hexyl ester   Rhodamine B, hexyl ester, perchlorate
OMe Methyl ester   TMRM [Tetramethylrhodamine methyl ester] *CAS#: 115532-50-8*
D-Luciferin methyl ester *CAS 73918-26-0*
ONp p-Nitrophenyl ester    
OPcp Pentachlorophenyl ester    
OPfp Pentafluorophenyl ester    
OPh Phenyl ester    
OSu Succinimide ester   ICG-OSu
ICG-Sulfo-OSu
ICG Xtra-OSu
OcHex Cyclohexyl ester    
Oic L-Octahydroindole-2-carboxylic acid    
Orn Ornithine    
OtBu t-Butyl ester    
PEG Polyethylene glycol   FMOC-Glu(biotinyl-PEG)-OH
Glucose-UDP-(PEG)6-Fluorescein Conjugate
MM(PEG)24 Methyl-PEG-Maleimide Reagent
PEG2 Polyethylene glycol --CH2-CH2-O-CH2-CH2-O-CH2-CH2-- Biotin PEG2 amine *CAS 138529-46-1*
Biotin PEG2 maleimide *CAS 305372-39-8*
Biotin PEG2 succinimidyl ester
PEG4 Polyethylene glycol --CH2-CH2-O-CH2-CH2-O-CH2-CH2-O-CH2-CH2-O-CH2-CH2-- Biotin PEG4 succinimidyl ester
Phalloidin-PEG4-DBCO
DBCO-PEG4-NHS Ester
Pal 2-Pyridylalanine   (Ac-PAL)2R110
Palmitoyl Palmitic acid group    
Pbf 2,2,4,6,7-Pentamethyldihydrobenzofuran-5-sulfonyl    
Pen L-Penicillamine β,β-Dimethyl-L-cysteine  
Phaa Phenylacetic acid    
Phg L-Phenylglycine    
Pmp β-Mercapto-β,β-cyclopentamethylene propionic acid    
R110 Rhodamine 110   Rhodamine 110 *CAS 13558-31-1*
Bis-L-Aspartic acid Beta-rhodamine 110
Bis-Arg-rhodamine 110
Sar Sarcosine N-Methylglycine  
Sta Statyl-((3S,4S)-4-amino-3-hydroxy-6-methylheptanoyl)   BOC-Statine [BOC-Sta(3S,4S)-OH] *CAS 58521-49-6*
FMOC-Statine [FMOC-Sta(3S,4S)-OH] *CAS 158257-40-0*
Suc Succinyl   Suc-LLVY-AMC
(Suc-LLVY)2R110
Suc-LLVY-Aminoluciferin
TAMRA Carboxytetramethyl rhodamine   5(6)-TAMRA [5(6)-Carboxytetramethylrhodamine] *CAS 98181-63-6*
6-TAMRA, SE [6-Carboxytetramethylrhodamine, succinimidyl ester] *CAS#: 150810-69-8*
5(6)-TAMRA, SE [5-(and-6)-Carboxytetramethylrhodamine, succinimidyl ester] *CAS 246256-50-8*
Tfa Trifluoroacetyl    
Thi β-2-Thienylalanine    
Tic L-1,2,3,4-Tetrahydroisoquinoline-3-carboxylic acid    
Tle tert-butyl-leucine    
Tos Tosyl 4-Toluenesulfonyl  
Trt Trityl triphenylmethyl
Tr
 
Tyr(Me) Methyltyrosine    
Xan Xanthyl    
gamma-Glu γ-L-Glutamyl-    
iPr iso-propyl    
p-nitro-Phe para-nitro-phenylalanine    
pNA p-Nitroanilide   Ac-DEVD-pNA *CAS 189950-66-1*
Z-IETD-pNA *CAS 219138-21-3*
Z-DEVD-pNA
pSer Phospho-L-serine    
pThr Phospho-L-threonine    
pTyr Phospho-L-tyrosine    
tBu t-Butyl    
β-NA β-Naphthylamide    


Original created on April 24, 2020, last updated on April 24, 2020
Tagged under: Oligonucleotide Labeling, Peptide Labeling