PE Mouse Anti-human/horse EGFR Antibody *EGFR1, monoclonal, Cross Adsorbed*
Ordering information
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Additional ordering information
Telephone | 1-800-990-8053 |
Fax | 1-800-609-2943 |
sales@aatbio.com | |
International | See distributors |
Bulk request | Inquire |
Custom size | Inquire |
Shipping | Standard overnight for United States, inquire for international |
Storage, safety and handling
Intended use | Research Use Only (RUO) |
Overview | Protocol |
See also: Antibodies and Proteomics
Other names | Clone EGFR1 | Host mouse | Reactivity human; horse | Application FC (QC TESTED) |
Epidermal growth factor receptor is a 134 kDa transmembrane protein that can be located in the plasma membrane, protein-containing complex and apical plasma membrane of cells. It is alternatively called receptor tyrosine-protein kinase erbB-1 and proto-oncogene c-ErbB-1. In humans, epidermal growth factor receptor is the subject of extensive examination in part because of the fact that it is involved with the epidermal growth factor receptor signaling pathway, negative regulation of epidermal growth factor receptor signaling pathway and ERBB2 signaling pathway, and moreover, has been associated with essential functions such as transmembrane receptor protein tyrosine kinase, protein tyrosine kinase and epidermal growth factor-activated receptor activity. It binds with protein kinase, calmodulin and ATPase. Sequencing of epidermal growth factor receptor has supported it contains 3 conserved structural units: cytoplasmic, extracellular and protein kinase domain. Epidermal growth factor receptor enhances DNA-templated transcription, smooth muscle cell proliferation and DNA replication. But it also suppresses apoptotic process, mitotic cell cycle and protein catabolic process. It takes part in organismal processes, for instance, ossification, salivary gland morphogenesis and cell-cell adhesion. It takes part in processes such as nitric-oxide synthase activity, transcription by RNA polymerase II and cell motility. Mutations and abnormalities in epidermal growth factor receptor have been associated with a number of diseases, for example, neonatal inflammatory skin and bowel disease-2 (NISBD2) and lung cancer (LNCR). Neonatal inflammatory skin and bowel disease-2, an autosomal recessive inheritancedisorder characterized by diarrhea, epidermal acanthosis and dehydration, has especially been of interest to scientists.
Conjugation
We provide custom conjugation services for this antibody (eg. labeling of EGFR antibody with HRP). A list of available labels can be found in the table below:
For additional information about custom conjugations, please consult our services page here.
AF | AF350, AF488, AF555, AF594, AF647, AF680, AF700, AF750 |
Proteins | HRP, Alkaline Phosphatase, Streptavidin |
Tandems | APC, APC/Cy7, APC/AF750, APC/iFluor™ 700, APC/iFluor™ 750, PE, PE/Cy5, PE/Cy7, PE/AF610, PE/AF700, PE/iFluor™ 594, PE/iFluor™ 647, PE/iFluor™ 700, PE/iFluor™ 750, PE/Texas Red®, PerCP, PerCP/Cy5.5 |
Small Molecules | Biotin |
Traditional Dyes | FITC (fluorescein), TRITC, PacBlue, PacOrange, Cy3, Cy5 |
iFluor | 350, 405, 430, 450, 488, 514, 532, 546, 555, 560, 568, 594, 610, 633, 647, 660, 670, 680, 700, 710, 750, 790, 800, 810, 820, 840, 860, A7 |
mFluor | UV375, UV460, Violet 450, Violet 500, Violet 510, Violet 540, Blue 570, Green 620, Red 700, Red 780 |
For additional information about custom conjugations, please consult our services page here.
Application notes
A New Protein Crosslinking Method for Labeling and Modifying Antibodies
A Novel Fluorescent Probe for Imaging and Detecting Hydroxyl Radical in Living Cells
A Novel NO Wash Probeniceid-Free Calcium Assay for Functional Analysis of GPCR and Calcium Channel Targets
Biotin Labeling Molecules and Their Biological Applications
Buccutite™ Bioconjugation Technology
A Novel Fluorescent Probe for Imaging and Detecting Hydroxyl Radical in Living Cells
A Novel NO Wash Probeniceid-Free Calcium Assay for Functional Analysis of GPCR and Calcium Channel Targets
Biotin Labeling Molecules and Their Biological Applications
Buccutite™ Bioconjugation Technology
FAQ
How can I lyse my cells without lysing the nuclear membrane?
What are the differences between calcium ion indicators: Cal 520, Cal 520FF, and Cal 520N?
How do I make an AM ester stock solution?
Can we fix cells with glutaraldehyde and then stain with fluorescent phalloidin?
What is the difference between FluoroQuest Anti-fading Kit I and FluoroQuest Anti-fading Kit II?
What are the differences between calcium ion indicators: Cal 520, Cal 520FF, and Cal 520N?
How do I make an AM ester stock solution?
Can we fix cells with glutaraldehyde and then stain with fluorescent phalloidin?
What is the difference between FluoroQuest Anti-fading Kit I and FluoroQuest Anti-fading Kit II?