XFD350 Anti-human CD44 Antibody *HERMES-1, XFD350 Same Structure to Alexa Fluor™ 350*
HERMES-1 is an anti-human monoclonal antibody that forms an immune complex with the CD44 antigen. CD44 (sometimes called Hermes, H-CAM, ECMR III or PGP-1) is a 85 kD transmembrane glycoprotein that is expressed on the surface of cells like erythrocytes, NK cells and epithelial cells. In many organisms, CD44 is involved in the negative regulation of apoptotic process, upregulates peptidyl-serine phosphorylation and is a positive regulator of ERK1 and ERK2 cascade. Additionally, it plays a role in vital cellular pathways, for example, the negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator and interferon-gamma-mediated signaling pathway. From a research standpoint, it is of biological interest due to its association with important macromolecules/ligands such as Hyaluronan. CD44 is a very popular antibody target, with over 45000 publications in the last decade. CD44 is frequently used in flow cytometry applications as a phenotypic marker for differentiation of cell types, especially in the study of cell biology, immunology and cell adhesion. This antibody was purified through affinity chromatography and conjugated to XFD350 (ex/em = 343/441 nm). XFD350 is manufactured by AAT Bioquest, and it has the same chemical structure of Alexa Fluor® 350 (Alexa Fluor® is the trademark of ThermoFisher). It is compatible with the 355 nm laser and 447/60 nm bandpass filter (for example, as in the Bio-Rad ZE5 Cell Analyzer).
Spectrum
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Conjugation
We provide custom conjugation services for this antibody (eg. labeling of cd44 antibody with HRP). A list of available labels can be found in the table below:
For additional information about custom conjugations, please consult our services page here.
AF | AF350, AF488, AF555, AF594, AF647, AF680, AF700, AF750 |
Proteins | HRP, Alkaline Phosphatase, Streptavidin |
Tandems | APC, APC/Cy7, APC/AF750, APC/iFluor™ 700, APC/iFluor™ 750, PE, PE/Cy5, PE/Cy7, PE/AF610, PE/AF700, PE/iFluor™ 594, PE/iFluor™ 647, PE/iFluor™ 700, PE/iFluor™ 750, PE/Texas Red®, PerCP, PerCP/Cy5.5 |
Small Molecules | Biotin |
Traditional Dyes | FITC (fluorescein), TRITC, PacBlue, PacOrange, Cy3, Cy5 |
iFluor | 350, 405, 430, 450, 488, 514, 532, 546, 555, 560, 568, 594, 610, 633, 647, 660, 670, 680, 700, 710, 750, 790, 800, 810, 820, 840, 860, A7 |
mFluor | UV375, UV460, Violet 450, Violet 500, Violet 510, Violet 540, Blue 570, Green 620, Red 700, Red 780 |
For additional information about custom conjugations, please consult our services page here.
Page updated on December 13, 2024