CHAPS Detergent

Type	Zwitterionic
Molecular Weight	615
Molecular Formula	C₃₂H₅₈N₂O₇S
Critical Micelle Concentration (CMC) ^(?)	6-10
Solubility	Water soluble
Conductivity	<25µS in a 10% solution
Aggregation number	10
Cloud point	>100°C
Average micellar weight	6,150
Applications	CHAPS is a non-denaturing, electrically neutral, sulfobetaine dtergent. It is used for solubilizing membrane proteins and breaking protein-protein interactions. It causes less protein aggregation than non ionic detergents and is capable of solubilizing poiate receptors. CHAPS can be removed from proteins by detergent removing gel or dialysis.
Chemical Structure

List of detergents

Detergent Name	CMC	Type
ASB-14	8	Zwitterionic
ASB-14-4	-	Zwitterionic
ASB-16	8	Zwitterionic
ASB-C7BzO	-	Zwitterionic
ASB-C8ø	-	Zwitterionic
Big CHAP	3.4	Non-ionic
Brij® 35	0.09	Non-ionic
Brij® 58	0.007-0.077	Non-ionic
C₁₂E₈	0.11	Non-ionic
CHAPS	6-10	Zwitterionic
CHAPSO	8	Zwitterionic
CTAB	1	Cationic
Cyclohexyl-n-hexyl-β-D-maltoside	0.56	Non-ionic
DDMAB	4.3	Zwitterionic
Deoxy Big CHAP	1.1-1.4	Non-ionic
Deoxycholate	4-8	Anionic
Digitonin	0.2-0.73	Non-ionic
HECAMEG	19.5	Non-ionic
MEGA 10	6-7	Non-ionic
MEGA 8	58	Non-ionic
MEGA 9	19-25	Non-ionic
n-Decanoylsucrose	2.5	Non-ionic
n-Decyl-β-D-maltopyranoside	1.6	Non-ionic
n-Dodecanoylsucrose	0.3	Non-ionic
n-Dodecyl-β-D-glucopyranoside	0.13	Non-ionic
n-Dodecyl-β-D-maltoside	0.1-0.6	Non-ionic
n-Heptyl-β-D-glucopyranoside	79	Non-ionic
n-Heptyl-β-D-thioglucopyranoside	30	Non-ionic
n-Hexyl-β-D-glucopyranoside	250	Non-ionic
n-Nonyl-β-D-glucopyranoside	6.5	Non-ionic
n-Octanoylsucrose	24.4	Non-ionic
n-Octyl-β-D-glucopyranoside	20-25	Non-ionic
n-Octyl-β-D-maltopyranoside	23.4	Non-ionic
n-Octyl-β-D-thioglucopyranoside	9	Non-ionic
Nonidet® P-40 Substitute	0.05-0.3	Non-ionic
Octyl β Glucoside	20-25	Non-ionic
SDS	7-10	Anionic
Sulfobetaine 3-10 (SB 3-10)	25-40	Zwitterionic
Sulfobetaine 3-12 (SB 3-12)	2-4	Zwitterionic
Sulfobetaine 3-14 (SB 3-14)	0.1-0.4	Zwitterionic
Triton® X-100	0.2	Non-ionic
Triton® X-114	0.35	Non-ionic
Tween® 20	0.06	Non-ionic
Tween® 80	0.012	Non-ionic
ZWITTERGENT® 3-10	25-40	Zwitterionic
ZWITTERGENT® 3-12	2-4	Zwitterionic
ZWITTERGENT® 3-14	0.1-0.4	Zwitterionic
ZWITTERGENT® 3-16	0.01-0.06	Zwitterionic

References

This online resource may be cited as follows

MLA	"Quest Database™ CHAPS Detergent." AAT Bioquest, Inc., 25 Nov. 2025, https://www.aatbio.com/resources/biological-detergents-properties-and-applications/chaps.
APA	AAT Bioquest, Inc. (2025, November 25). Quest Database™ CHAPS Detergent. AAT Bioquest. https://www.aatbio.com/resources/biological-detergents-properties-and-applications/chaps.
BibTeX	EndNote	RefMan