Sulfobetaine 3-12 (SB 3-12) Detergent

Type	Zwitterionic
Molecular Weight	336
Molecular Formula	CH₃(CH₂)₁₁N⁺(CH₃)₂CH₂CH₂CH₂SO₃^-
Critical Micelle Concentration (CMC) ^(?)	2-4
Solubility	Water soluble
Aggregation number	55
Average micellar weight	18,500
Applications	Sulfobetaine 3-12 is a detergent used for the solubilization of membrane proteins in their native state.
Chemical Structure

List of detergents

Detergent Name	CMC	Type
ASB-14	8	Zwitterionic
ASB-14-4	-	Zwitterionic
ASB-16	8	Zwitterionic
ASB-C7BzO	-	Zwitterionic
ASB-C8ø	-	Zwitterionic
Big CHAP	3.4	Non-ionic
Brij® 35	0.09	Non-ionic
Brij® 58	0.007-0.077	Non-ionic
C₁₂E₈	0.11	Non-ionic
CHAPS	6-10	Zwitterionic
CHAPSO	8	Zwitterionic
CTAB	1	Cationic
Cyclohexyl-n-hexyl-β-D-maltoside	0.56	Non-ionic
DDMAB	4.3	Zwitterionic
Deoxy Big CHAP	1.1-1.4	Non-ionic
Deoxycholate	4-8	Anionic
Digitonin	0.2-0.73	Non-ionic
HECAMEG	19.5	Non-ionic
MEGA 10	6-7	Non-ionic
MEGA 8	58	Non-ionic
MEGA 9	19-25	Non-ionic
n-Decanoylsucrose	2.5	Non-ionic
n-Decyl-β-D-maltopyranoside	1.6	Non-ionic
n-Dodecanoylsucrose	0.3	Non-ionic
n-Dodecyl-β-D-glucopyranoside	0.13	Non-ionic
n-Dodecyl-β-D-maltoside	0.1-0.6	Non-ionic
n-Heptyl-β-D-glucopyranoside	79	Non-ionic
n-Heptyl-β-D-thioglucopyranoside	30	Non-ionic
n-Hexyl-β-D-glucopyranoside	250	Non-ionic
n-Nonyl-β-D-glucopyranoside	6.5	Non-ionic
n-Octanoylsucrose	24.4	Non-ionic
n-Octyl-β-D-glucopyranoside	20-25	Non-ionic
n-Octyl-β-D-maltopyranoside	23.4	Non-ionic
n-Octyl-β-D-thioglucopyranoside	9	Non-ionic
Nonidet® P-40 Substitute	0.05-0.3	Non-ionic
Octyl β Glucoside	20-25	Non-ionic
SDS	7-10	Anionic
Sulfobetaine 3-10 (SB 3-10)	25-40	Zwitterionic
Sulfobetaine 3-12 (SB 3-12)	2-4	Zwitterionic
Sulfobetaine 3-14 (SB 3-14)	0.1-0.4	Zwitterionic
Triton® X-100	0.2	Non-ionic
Triton® X-114	0.35	Non-ionic
Tween® 20	0.06	Non-ionic
Tween® 80	0.012	Non-ionic
ZWITTERGENT® 3-10	25-40	Zwitterionic
ZWITTERGENT® 3-12	2-4	Zwitterionic
ZWITTERGENT® 3-14	0.1-0.4	Zwitterionic
ZWITTERGENT® 3-16	0.01-0.06	Zwitterionic

References

This online resource may be cited as follows

MLA	"Quest Database™ Sulfobetaine 3-12 (SB 3-12) Detergent." AAT Bioquest, Inc., 17 Oct. 2025, https://www.aatbio.com/resources/biological-detergents-properties-and-applications/sulfobetaine-3-12-sb-3-12.
APA	AAT Bioquest, Inc. (2025, October 17). Quest Database™ Sulfobetaine 3-12 (SB 3-12) Detergent. AAT Bioquest. https://www.aatbio.com/resources/biological-detergents-properties-and-applications/sulfobetaine-3-12-sb-3-12.
BibTeX	EndNote	RefMan