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Is ATP required to provide energy for actin polymerization?

Posted November 4, 2022


Actin
Bioconjugation
Cell Signaling
Cellular Processes
Enzymes
Cell Proliferation
Answer

ATP is not always required to provide energy for actin polymerization. However, actin monomers polymerize more readily when bound to ATP as compared to actin monomers that are bound to ADP. Binding with ATP and ATP hydrolysis play integral roles in mediating the assembly and dynamic behavior of actin filaments. 

Additional resources

ATP-dependent regulation of actin monomer-filament equilibrium by cyclase-associated protein and ADF/cofilin

PhosphoWorks™ Fluorimetric ADP Assay Kit *Red Fluorescence*

PhosphoWorks™ Luminometric ATP Assay Kit *Bright Glow*

Actin

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