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Xylazine-KLH Conjugate

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Physical properties
SolventWater
Storage, safety and handling
H-phraseH303, H313, H333
Hazard symbolXN
Intended useResearch Use Only (RUO)
R-phraseR20, R21, R22
StorageFreeze (< -15 °C); Minimize light exposure
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OverviewpdfSDSpdfProtocol


Xylazine-KLH conjugate is an excellent antigen for developing anti-Xylazine antibodies for ELISA-based assays and tests for detecting Xylazine. Xylazine is a non-opioid sedative or tranquilizer. It is not approved for use in people. It is commonly used in veterinary medicine for sedation, anesthesia, muscle relaxation, and analgesia in animals such as horses, cattle, and other mammals. In veterinary anesthesia, it is often combined with ketamine. Veterinarians also use xylazine as an emetic, especially in cats.

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References


View all 12 references: Citation Explorer
Prevalence of xylazine among people who inject drugs seeking medical care at a syringe services program clinic: Miami, Florida, 2023.
Authors: Hauschild, Maia H and Warp, Peyton V and Tookes, Hansel E and Yakir, Ella and Malhotra, Bharat and Malik, Subul and Owens, Cyrus and Suarez, Edward and Serota, David P and Bartholomew, Tyler S
Journal: Drug and alcohol dependence reports (2023): 100209
An ultrasensitive monoclonal antibody-based lateral flow immunoassay for the rapid detection of xylazine in milk.
Authors: Chen, Linlin and Hu, Xiaofei and Sun, Yaning and Xing, Yunrui and Zhang, Gaiping
Journal: Food chemistry (2022): 132293
Recombinant human hyaluronidase PH20-mediated dermal spreading activity in mice is not altered by steroids, antihistamines, or salicylic acid.
Authors: Cowell, Jessica A and Printz, Marie A and Thompson, Curtis B
Journal: Drug metabolism and personalized therapy (2020)
Targeting CD44 expressing cancer cells with anti-CD44 monoclonal antibody improves cellular uptake and antitumor efficacy of liposomal doxorubicin.
Authors: Arabi, Leila and Badiee, Ali and Mosaffa, Fatemeh and Jaafari, Mahmoud Reza
Journal: Journal of controlled release : official journal of the Controlled Release Society (2015): 275-286
Effect of chlorpyrifos on the profile of subpopulations immunocompetent cells B, T and NK in in vivo model.
Authors: Noworyta-Głowacka, Justyna and Beresińska, Martyna and Bańkowski, Robert and Wiadrowska, Bożena and Siennicka, Joanna and Ludwicki, Jan K
Journal: Roczniki Panstwowego Zakladu Higieny (2014): 311-6
Bevacizumab accelerates corneal wound healing by inhibiting TGF-beta2 expression in alkali-burned mouse cornea.
Authors: Lee, Sung Ho and Leem, Hyun Sung and Jeong, Seon Mi and Lee, Koonja
Journal: BMB reports (2009): 800-5
Hepatic leukocyte recruitment in response to time-limited expression of TNF-alpha and IL-1beta.
Authors: Patrick, Amanda L and Rullo, Jacob and Beaudin, Suzanne and Liaw, Patricia and Fox-Robichaud, Alison E
Journal: American journal of physiology. Gastrointestinal and liver physiology (2007): G663-72
Spatiotemporal quantification of recruit and resident macrophages after crush nerve injury utilizing immunohistochemistry.
Authors: Omura, Takao and Omura, Kumiko and Sano, Michio and Sawada, Tomokazu and Hasegawa, Tomohiko and Nagano, Akira
Journal: Brain research (2005): 29-36
Immunofluorescence mapping of dystrophin in the rat brain: astrocytes contain the splice variant Dp71f, but this is confined to subpopulations.
Authors: Szabó, Adrienn and Jancsik, Veronika and Mornet, Dominique and Kálmán, Mihály
Journal: Anatomy and embryology (2004): 463-77
Intraocular pharmacokinetics and safety of a humanized monoclonal antibody in rabbits after intravitreal administration of a solution or a PLGA microsphere formulation.
Authors: Mordenti, J and Thomsen, K and Licko, V and Berleau, L and Kahn, J W and Cuthbertson, R A and Duenas, E T and Ryan, A M and Schofield, C and Berger, T W and Meng, Y G and Cleland, J
Journal: Toxicological sciences : an official journal of the Society of Toxicology (1999): 101-6