cAMP-NHS ester

Cyclic adenosine monophosphate (cAMP) is a second messenger used for intracellular signal induction. It is synthesized from adenosine triphosphate (ATP) by enzymes (g-proteins) that are attached to metabotropic receptors and become released when the receptor is activated. Cyclic AMP is involved in the regulation of glycogen, sugar, and lipid metabolism. This cAMP NHS ester is an excellent building block that can be used for developing cAMP probes and assays.

Protocol

SDS

COA

Catalog	Size	Price	Quantity
17102	1 mg	Price

Calculators

Common stock solution preparation

Table 1. Volume of DMSO needed to reconstitute specific mass of cAMP-NHS ester to given concentration. Note that volume is only for preparing stock solution. Refer to sample experimental protocol for appropriate experimental/physiological buffers.

	0.1 mg	0.5 mg	1 mg	5 mg	10 mg
1 mM	146.062 µL	730.311 µL	1.461 mL	7.303 mL	14.606 mL
5 mM	29.212 µL	146.062 µL	292.124 µL	1.461 mL	2.921 mL
10 mM	14.606 µL	73.031 µL	146.062 µL	730.311 µL	1.461 mL

Molarity calculator

Enter any two values (mass, volume, concentration) to calculate the third.

Mass (Calculate)		Molecular weight		Volume (Calculate)		Concentration (Calculate)		Moles
mg	÷	684.64 g/mol	=	mL	x	mM	=	mmol

Citations

View all 59 citations: Citation Explorer

Roles of Cyclic AMP Response Element Binding Activation in the ERK1/2 and p38 MAPK Signalling Pathway in Central Nervous System, Cardiovascular System, Osteoclast Differentiation and Mucin and Cytokine Production

Authors:

Koga, Y., Tsurumaki, H., Aoki-Saito, H., Sato, M., Yatomi, M., Takehara, K., Hisada, T.

Journal:

Int J Mol Sci (2019): ersion="1.0" encoding="UTF-8" ?>17102.enlEndN

Making and Breaking of an Essential Poison: the Cyclases and Phosphodiesterases That Produce and Degrade the Essential Second Messenger Cyclic di-AMP in Bacteria

Authors:

Commichau, F. M., Heidemann, J. L., Ficner, R., Stulke, J.

Journal:

J Bacteriol (2019): se name="17102.enl" path="C:\Users\aatbi\Drop

Cyclic di-AMP in host-pathogen interactions

Authors:

Devaux, L., Kaminski, P. A., Trieu-Cuot, P., Firon, A.

Journal:

Curr Opin Microbiol (2018): 21-28

Natural products as modulators of the cyclic-AMP pathway: evaluation and synthesis of lead compounds

Authors:

Sengupta, S., Mehta, G.

Journal:

Org Biomol Chem (2018): 6372-6390

Perspective of ions and messengers: an intricate link between potassium, glutamate, and cyclic di-AMP

Authors:

Gundlach, J., Commichau, F. M., Stulke, J.

Journal:

Curr Genet (2018): 191-195

Physical properties

Molecular weight	684.64
Solvent	DMSO

Storage, safety and handling

Intended use	Research Use Only (RUO)
Storage	Freeze (< -15 °C); Minimize light exposure

Documents

Protocol
Safety Data Sheet
Certificate of Analysis

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Page updated on October 18, 2025