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Investigating Intercellular Channels: Focus on Gap Junctions
One of the main three types of intercellular junctions, gap junctions are crucial for several cell communication pathways, and any dysregulation can have immediate and lethal effects. They have been implicated in tumor development and the inflammatory response in general, as well as standard cellular regulation. Given this importance, being able to investigate gap junction activity is useful for several fields of study. Using fluorescent labels is one of the simpler ways to experimentally determine gap junction activity within a cell population. Fluorescent labels can be adapted and optimized for various cell lines, experimental setups, and instrument platforms. Either a flow cytometer or fluorescence microscope can be used to analyze gap junction activity. Read latest issue ...


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