iFluor® 780 succinimidyl ester

AAT Bioquest's iFluor® dyes are optimized for labeling proteins, particularly antibodies. These dyes are bright, photostable, and have minimal quenching on proteins. They can be well excited by the major laser lines of fluorescence instruments (e.g., 350, 355, 405, 488, 555, 633, 638, 647, 660, and 802 nm). iFluor® 780 is an excellent acceptor dye for preparing tandem colors with APC and PE. These iFluor® 780 tandem colors offer a set of unique color profiles for spectral flow cytometry. iFluor® 780 is one of the brightest NIR dyes, and some of its antibody conjugates are significantly brighter than those prepared with IRDyes of similar wavelengths, such as IRDye 800CW. iFluor® 780 succinimidyl ester is an amine-reactive form used to conjugate with amine-containing molecules such as antibodies and peptides.

Protocol

SDS

COA

Catalog	Size	Price	Quantity
1371	1 mg	Price

References

View all 50 references: Citation Explorer

Metastatic and sentinel lymph node mapping using intravenously delivered Panitumumab-IRDye800CW.

Authors:

Krishnan, Giri and van den Berg, Nynke S and Nishio, Naoki and Juniper, Georgina and Pei, Jaqueline and Zhou, Quan and Lu, Guolan and Lee, Yu-Jin and Ramos, Kimberly and Iagaru, Andrei H and Baik, Fred M and Colevas, Alexander D and Martin, Brock A and Rosenthal, Eben L

Journal:

Theranostics (2021): 7188-7198

Effect of Formalin Fixation for Near-Infrared Fluorescence Imaging with an Antibody-Dye Conjugate in Head and Neck Cancer Patients.

Authors:

Kapoor, Shrey and Lu, Guolan and van den Berg, Nynke S and Krishnan, Giri and Pei, Jacqueline and Zhou, Quan and Martin, Brock A and Baik, Fred M and Rosenthal, Eben L and Nishio, Naoki

Journal:

Molecular imaging and biology (2021): 270-276

Structurally symmetric near-infrared fluorophore IRDye78-protein complex enables multimodal cancer imaging.

Authors:

Yang, Jiang and Zhao, Chunhua and Lim, Jacky and Zhao, Lina and Tourneau, Ryan Le and Zhang, Qize and Dobson, Damien and Joshi, Suhasini and Pang, Jiadong and Zhang, Xiaodong and Pal, Suchetan and Andreou, Chrysafis and Zhang, Hanwen and Kircher, Moritz F and Schmitthenner, Hans

Journal:

Theranostics (2021): 2534-2549

Safety and Stability of Antibody-Dye Conjugate in Optical Molecular Imaging.

Authors:

Pei, Jacqueline and Juniper, Georgina and van den Berg, Nynke S and Nisho, Naoki and Broadt, Trevor and Welch, Anthony R and Yi, Grace S and Raymundo, Roan C and Chirita, Stefania U and Lu, Guolan and Krishnan, Giri and Lee, Yu-Jin and Kapoor, Shrey and Zhou, Quan and Colevas, A Dimitrios and Lui, Natalie S and Poultsides, George A and Li, Gordon and Zinn, Kurt R and Rosenthal, Eben L

Journal:

Molecular imaging and biology (2021): 109-116

Evaluation of Ac-Lys0(IRDye800CW)Tyr3-octreotate as a novel tracer for SSTR2-targeted molecular fluorescence guided surgery in meningioma.

Authors:

Dijkstra, Bianca M and de Jong, Marion and Stroet, Marcus C M and Andreae, Fritz and Dulfer, Sebastiaan E and Everts, Marieke and Kruijff, Schelto and Nonnekens, Julie and den Dunnen, Wilfred F A and Kruyt, Frank A E and Groen, Rob J M

Journal:

Journal of neuro-oncology (2021): 211-222

Physical properties

Molecular weight	1526.90
Solvent	DMSO

Spectral properties

Absorbance (nm)	779
Correction factor (260 nm)	0.13
Correction factor (280 nm)	0.12
Extinction coefficient (cm ^-1 M ^-1)	250000 ¹
Excitation (nm)	784
Emission (nm)	808
Quantum yield	0.16 ¹

Storage, safety and handling

H-phrase	H303, H313, H333
Hazard symbol	XN
Intended use	Research Use Only (RUO)
R-phrase	R20, R21, R22
Storage	Freeze (< -15 °C); Minimize light exposure
UNSPSC	12171501

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Page updated on September 29, 2025