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iFluor® 860 maleimide
In vivo fluorescence imaging uses a sensitive camera to detect the fluorescence emission from fluorophores in whole-body living small animals. To overcome the photon attenuation in living tissue, fluorophores with long emission at the infrared (IR) region are generally preferred. Recent advances in imaging strategies and reporter techniques for in vivo fluorescence imaging include novel approaches to improve the specificity and affinity of the probes and to modulate and amplify the signal at target sites for enhanced sensitivity. Further emerging developments aim to achieve high-resolution, multimodality, and lifetime-based in vivo fluorescence imaging. Our iFluor® 860 is designed to label proteins and other biomolecules with infrared fluorescence. Conjugates prepared with iFluor® 860 have excitation and emission in the IR range. iFluor® 860 dye emission is well separated from commonly used far-red fluorophores such as Cy5, Cy7, or allophycocyanin (APC), facilitating multicolor analysis. This fluorophore is also useful for small animal in-vivo imaging applications or other imaging applications requiring IR detection. iFluor® 860 maleimide is thiol-reactive and can be readily used to conjugate thiol-containing biomolecules.
<p>Fluorescent dye maleimides (e.g., iFluor 860 maleimide) are the most popular tool for conjugating dyes to a peptide, protein, antibody, thiol-modified oligonucleotide or nucleic acid through their SH group. Maleimides react readily with the thiol group of proteins, thiol-modified oligonucleotides, and other thiol-containing molecules under neutral conditions. The resulting dye conjugates are quite stable.</p>
<p>Fluorescent dye maleimides (e.g., iFluor 860 maleimide) are the most popular tool for conjugating dyes to a peptide, protein, antibody, thiol-modified oligonucleotide or nucleic acid through their SH group. Maleimides react readily with the thiol group of proteins, thiol-modified oligonucleotides, and other thiol-containing molecules under neutral conditions. The resulting dye conjugates are quite stable.</p>
protocol
Protocol
sds
SDS
COO
COA
CatalogSize
Price
Quantity
14081 mg
Price
 
Physical properties
Molecular weight1647.66
SolventDMSO
Spectral properties
Correction factor (260 nm)0.1
Correction factor (280 nm)0.14
Extinction coefficient (cm -1 M -1)
250000
1
Excitation (nm)853
Emission (nm)878
Storage, safety and handling
Certificate of OriginDownload PDF
H-phraseH303, H313, H333
Hazard symbolXN
Intended useResearch Use Only (RUO)
R-phraseR20, R21, R22
StorageFreeze (< -15 °C); Minimize light exposure
UNSPSC12171501
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Page updated on October 7, 2025